Nutritional Outlook

Nutritional Outlook, June 2018

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Antioxidants ■ NUTRITIONAL OUTLOOK 36 JUNE 2018 artery (an indicator of arterial stif ness), and cerebrovascular responsiveness (CVR) to both cognitive testing and hypercapnia (carbon-di- oxide retention). T e subjects also completed mood questionnaires. Relative to the placebo, resveratrol elicited 17% increases in CVR to both hypercapnic and cognitive stimuli, as well as signif cant improvements in verbal memory tasks and overall cognitive performance. T ough mood improved on multiple measures in the resver- atrol group, the changes weren't signif cant. In addition to showing that resveratrol supplementation can enhance cerebrovas- cular function and cognition in postmeno- pausal women, the results "suggest that some of the observed ef ects on brain blood f ow may have real-world implications, espe- cially in the context of aging," Welsh says. Feel Good about Getting Older T e team of scientists responsible for the previous study examined another aspect of resveratrol's cerebrovascular ef ects in an in- tervention trial 2 that began with the premise that pain common among postmenopausal women and often related to degradative joint diseases like age-related osteoarthritis may be a product of the vascular dysfunction that comes with declining estrogen levels. So the researchers evaluated how supple- mentation with resveratrol might change that scenario. Once again, 80 healthy post- menopausal women took either 75 mg of res- veratrol twice daily, or a placebo, for 14 days. T e researchers measured aspects of wellbe- ing including pain, menopausal symptoms, sleep quality, depressive symptoms, mood, and quality of life at baseline and following treatment, with rating scales averaged to give a composite overall wellbeing score. Also, measures of cerebral vasodilator responsive- ness to hypercapnia served as a marker for cerebrovascular function. T e researchers found that compared to the placebo, resveratrol supplementation yielded a signif cant reduction in pain, and improvement in total wellbeing emerged— both of which, along with quality of life, correlated with improved cerebrovascular function. While more study is needed, the researchers write, the f ndings indicate res- veratrol's potential to reduce chronic pain in age-related osteoarthritis and possibly boost perceptions of wellbeing in postmenopausal women. Evolva's Adamski says the same group of researchers is conducting a bigger follow-up "Resveratrol science continues to grow with positive results," says Evolva's Gene Adamski.

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