Nutritional Outlook

Nutritional Outlook, May 2018

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■ NUTRITIONAL OUTLOOK 58 MAY 2018 Men's Health Mike Straus is a freelance journalist liv- ing in Kelowna, Canada. He has written for publications including Canadian Chi- ropractor Magazine, UX Booth, and Iconic Concierge Vancouver. "A global shortage of saw palmetto oil extract opened the door for adulterated products from mainland China to enter the market," Woodman says. "T ese adulter- ated products have the incorrect fatty acid prof le and are missing the expected sterols and fatty alcohols. Euromed has been sur- veying the market and notifying trade orga- nizations and industry stakeholders of this practice." Botanicals for Prostate and General Health Support Megan Luu, marketing manager for Gencor (Irvine, CA), says that Gencor is currently in the process of branding and trademark- ing a new men's health ingredient derived from a plant native to Brazil. She says that Gencor expects this new supplement to re- ceive GRAS status by the middle of 2018. Says Luu: "We've developed a new ingredi- ent, an extract from the leaves of Ageratum conyzoides, that has shown 5-alpha-reduc- tase inhibition activity in in vitro studies. T is ingredient has also shown good ef - cacy for prostate health in a human clinical study." T at human study—a double-blind, ran- domized, placebo-controlled clinical trial— followed 106 men between the ages of 41 and 76 with medically diagnosed benign prostatic hyperplasia for 12 weeks. Ninety- eight participants completed the study. Par- ticipants were assessed on the IPSS scale and were given 250 mg of Ageratum conyzoides or a placebo once per day. Secondary outcomes measured included testosterone and PSA levels as well as participant scores on the Ag- ing Males' Symptom Score and the Derogatis Interview for Sexual Functioning self-report. T e trial showed that Ageratum conyzoides caused a statistically signif cant reduction in total IPSS score as well as a statistically signif cant reduction in day- and nighttime urinary frequency. 8 Luu adds that, currently, Gencor's focus is on diversifying delivery systems for men's health products. "T is space has been lacking in innovation, specif cally around delivery systems, and has remained stale," she says. "Most applications are restricted to softgels. We've broadened the delivery system space by bringing in an ingredient that can be used in other delivery forms like tablets, capsules, powders, and sachets." Beyond the Prostate: New Opportunities in the Wider Men's Health Market Experts say the men's health supplement market in general, and the prostate health supplement market in particular, aren't just in the midst of diversifying product lines; the market is also developing a more compre- hensive and holistic approach to and under- standing of men's health problems. "I see the men's health market becoming more comprehensive as time goes on," Seipel says. "T ere are a few targeted ingredients that tend to dominate the market, and I'd like to see more innovation give way to a more multifaceted approach to men's health." Re- searching how lifestyle factors may af ect prostate health is increasingly important, she adds. At least one large-scale clinical trial is cur- rently examining the connection between lifestyle factors and prostate health. T e trial, dubbed the Men's Eating and Living Study, is following 464 American men between the ages of 50 and 80 who have early-stage pros- tate cancer. T e phase 3 randomized clinical trial, sponsored by the Alliance for Clinical Trials in Oncology in collaboration with the National Cancer Institute, ended last month. Preliminary results are expected soon. 9 Prostate health is one of the most estab- lished realms of men's health for supplement manufacturers to target, but new opportuni- ties for manufacturers of men's health sup- plements will likely occur both inside and outside the prostate arena. Gencor's Luu says that the men's health niche hasn't seen much innovation in the last 10 years, and while this makes the niche a fairly reliable space for brands, it also means the industry is overdue for a shake-up. Says Luu, "T e men's health supplement market has excellent growth potential, not just in prostate health, but also in healthy ag- ing, active lifestyle, and andropause." Graminex's May adds this: "T e market looks dif erent depending on whether you're targeting older men or younger men. With older men, you're talking prostate health ingredients. But with younger men, the products are more oriented around sports health—protein products, amino acids, etc." As the men's health market continues to diversify, new opportunities will call for new formulations and products to meet evolving consumer demands. Manufactur- ers and brands can capitalize on growing awareness of men's health issues with inno- vative formulations, strong research, and targeted marketing campaigns that reach household decision makers. References 1. Katz A et al. "A green and black tea extract benef ts urological health in men with lower urinary tract symptoms." Therapeutic Advances in Urology, vol. 6, no. 3 ( June 2014): 89-96 2. Herrlinger K et al. "A randomized double blind study of a green and black tea agent, AssuriTEA, in healthy male subjects." Functional Foods in Health and Dis- ease, vol. 5 no. 10 (October 2015): 350-364 3. Cai T et al. "Pollen extract in association with vita- mins provides early pain relief in patients af ected by chronic prostatitis/chronic pelvic pain syndrome." Experimental and Therapeutic Medicine, vol. 8, no. 4 (October 2014): 1032-1038 4. Schoendorfer N et al. "Urox containing concen- trated extracts of Crataeva nurvala stem bark, Eq- uisetum arvense stem and Lindera aggregate root, in the treatment of symptoms of overactive bladder and urinary incontinence: A phase 2, randomised, double-blind placebo controlled trial." BMC Com- plementary and Alternative Medicine, vol. 18, no. 1 ( January 2018): 42 5. Vidlar A et al. "Cranberry fruit powder (Flowens TM ) improves lower urinary tract symptoms in men: A double-blind, randomized, placebo-controlled study." World Journal of Urology, vol. 34, no. 3 (March 2016): 419-424 6. MJ Barry et al. "Ef ect of increasing doses of saw pal- metto extract on lower urinary tract symptoms." The Journal of the American Medical Association, vol. 306, no. 12 (September 28, 2011): 1344-1351 7. Pais P et al. "Determination of the potency of a novel saw palmetto supercritical CO 2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system." Research and Reports in Urology. Published online April 21, 2016. 8. Detering M et al. "Ageratum conyzoides L. inhibits 5-alpha-reductase gene expression in human pros- tate cells and reduces symptoms of benign prostatic hypertrophy in otherwise healthy men in a double blind randomized placebo controlled clinical study." BioFactors, vol. 43, no. 6 (November-December 2017): 789-800 9. Parsons JK. "T e men's eating and living (MEAL) study: A randomized trial of diet to alter disease progression in prostate cancer patients on active surveillance." Alliance for Clinical Trials in Oncology. Clinical Trial ID number NCT01238172. 10. Solan M. "Understanding the risks of supplements and herbal remedies for prostate cancer." Harvard Men's Health Watch ( July 2017). Published online July 20, 2017. 11. Ge B et al. "Updates on the clinical evidenced herb- warfarin interactions." Evidence-Based Complemen- tary and Alternative Medicine. Published online March 18, 2014.

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