Nutritional Outlook

Nutritional Outlook, May 2018

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■ NUTRITIONAL OUTLOOK 54 MAY 2018 Men's Health per day for 12 weeks caused a statistically significant increase in urine flow relative to a placebo and improved symptoms of LUTS. 1 A second randomized, double-blind, placebo-controlled clinical trial funded by Kemin examined the ef ects of AssuriTea on antioxidant concentrations in 43 healthy men between 25 and 70 years of age. Partici- pants were randomly assigned to a placebo or to 250 mg, 500 mg, or 1 g of AssuriTea for 28 days. T e study found that a daily 1-g dose of AssuriTea resulted in a statistically signif cant improvement in cellular antioxi- dant protection after 28 days relative to the placebo. 2 Fritz notes the signif cance of these anti- oxidant f ndings: "Prostate health issues are often caused by or exacerbated by inf am- mation and oxidative stress. T at's why As- suriTea provides both the anti-inf ammatory benef ts of black tea and the antioxidative benef ts of green tea." AssuriTea is targeted at the active lifestyle consumer, Fritz says, noting that Kemin's men's health ingredients fall under the um- brella of active wellness. She says this is no accident: marketing prostate health prod- ucts, she says, often requires a circuitous approach. "[Prostate health] is something that a lot of men aren't comfortable talking about, and a lot of household purchasers are female. So, our marketing campaign last year focused on the overall health and well-being angle," she says. "We talked about how a healthy lifestyle and AssuriTea supplementation work to- gether to provide health benef ts." Fritz says the next big evolution of the men's health and prostate health supple- ment market will involve a continuing em- phasis on safety. She also notes that botani- cal ingredients are growing in popularity. "Men's health has been a fairly stable space the last few years, but there's a larger demand for natural products. T e entire [nutritional supplement] market is moving in that direc- tion, so I expect men's health to move in that direction as well." Managing Pelvic Pain with Flower Pollen Extract Recent research by urologists in Italy dem- onstrated the ef ectiveness of pollen extract as a supplement for men with chronic pelvic pain due to prostatitis, or inf ammation of the prostate gland. Italian urological and sex- ual health supplement company IDIPharma recently published a randomized controlled clinical trial examining the ef ect of Deprox 500, a branded and patented supplement for- mulated with Graminex LLC's (Saginaw, MI) branded and patented Graminex f ower pol- len extract, on prostatitis-associated chronic pelvic pain in 87 males with a mean age of 33. Participants were randomized to take ei- ther two 500-mg tablets of Deprox per day or, in the case of the control group, 600 mg of ibuprofen (three 200-mg tablets) per day for four weeks. 3 After one month, both groups saw improvements in scores on the Nation- al Institutes of Health Chronic Prostatitis Symptom Index. But the Deprox group saw an approximately 50% reduction in its score, compared to just an approximately 25% re- duction for the ibuprofen group. Colleen May, public relations representa- tive for Graminex, says this study shows that Graminex's f ower pollen extract is ef ective at reducing prostatitis-associated pain. Says May: "IDIPharma found that our ingredient decreased the concentration of cytokines, spe- cif cally interleukins, in men with prostatitis." May says that pollen extract is gaining popularity as a prostate health supplement thanks to its natural origins and the fact that it represents a complex of compounds found in the raw ingredient, as opposed to, for instance, a pharmaceutical ingredient based on a single isolated compound. May says that she also expects food-based men's health supplements to continue growing. "We're noticing that a lot of formulators want to put our ingredients into foods," she says. "We've developed our own protein shakes that have pollen in them. A lot of the people taking our product are older ac- tive men with prostate issues, so the protein shake is a good way to deliver all the protein and amino acids needed to recover from a workout while also providing prostate health benef ts." She notes that product identif cation is becoming increasingly important as the mar- ket for men's health products grows. T e next major innovations in the men's health niche, May says, will involve further improvements in testing and verifying natural ingredients. "T ere's a push in the industry for better identity testing," she says. "T ere are a lot of products coming from overseas that claim to be from the United States. We've developed a lot of methods in house that we can send to our customers to ensure a product is what people say it is." Easing Overactive Bladder with Botanicals New data is emerging to demonstrate the usefulness of botanicals for addressing uri- nary issues in men. Tracey Seipel, ND, found- er of Australian supplements marketer Seipel Group, says that her company recently pub- lished a clinical trial on its branded bladder- control supplement Urox, a patented com- bination of botanicals like Crataeva nurvala stem bark, Equisetum arvense stem, and Lin- dera aggregata root. T e randomized, double-blind, placebo- controlled trial followed 150 participants (av- erage age 55) over the course of eight weeks. Participants took either 420 mg of Urox or a corresponding placebo once per day. T e tri- al measured urinary frequency by self-report at weeks zero, two, four, and eight. By the end of the trial, the active supplement group reported a 30% reduction in daytime urinary frequency and a 54% reduction in nocturia. T e placebo group saw lower reductions of 5% and 7%, respectively. T e active supple- ment group also saw statistically signif cant reductions in both urgency and total inconti- nence relative to the placebo group. 4 Seipel says that the ingredients in Urox may also assist with symptoms of prostate enlargement, but notes that the bladder- related symptoms typically ease before the prostate symptoms do. Seipel, who was one of the study authors, says that the subjects' improvements occurred in stages. T e uri- nary urgency symptoms saw statistically signif cant reductions by week two, she says, but the incontinence symptoms took four weeks to improve. Seipel Group's branded and patented Pro- rox supplement, designed to support overall prostate health, combines the Urox formula with 5-alpha-reductase, lycopene, and saw palmetto (Serenoa repens). Seipel says that botanicals will play an important role in prostate health supplements in the future, in conjunction with lifestyle factors.

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