Nutritional Outlook

Nutritional Outlook, April 2018

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■ NUTRITIONAL OUTLOOK 14 Supplement Safety APRIL 2018 The Search for HIDDEN STIMULANTS O ver the course of the many years I've spent analyzing dietary sup- plements, I've found potentially harmful ingredients hidden inside many of them. T ese include DMAA (1,3-dimeth- ylamylamine), DMBA (1,3-dimethylbutyl- amine), DEPEA (N,alpha-diethylphenyle- thylamine), and oxilofrine. In new research published in the peer-reviewed journal Clinical Toxicology 1 in November 2017, my co-authors and I highlight the presence of a newly emerging adulterant similar in struc- ture to DMAA: 2-aminoisoheptane. How We Learned about 2-Aminoisoheptane As researchers following the supplement in- dustry closely, my co-authors and I vigilantly monitor bodybuilding and workout blogs. In 2016, we learned about a new ingredient that had arrived on the scene: 2-aminoiso- heptane. None of us were familiar with this compound, and we could f nd no evidence that 2-aminoisoheptane could be considered a legitimate dietary ingredient. Based on its name, we suspected that this substance was an alkylamine, possibly related to DMAA and DMBA. Also, 2-aminoisoheptane has another interesting connection to DMAA and DMBA: all of these compounds were dis- cussed in studies of pressor amines originally published by Lilly Research Laboratories in the late 1940s. For our study, we decided to purchase products on the market claiming to contain the botanical ingredient Aconitum kusnezof- fii. Unscrupulous marketers will label prod- ucts as containing this botanical ingredient when really the products contain the syn- thetic 2-aminoisoheptane. We also searched for products listing 2-aminoisoheptane as an ingredient, as well as other terms used syn- onymously for 2-aminoisoheptane, includ- ing DMHA (dimethylhexylamine), 2-amino- 6-methylheptane (an analog of 1,3-DMAA, discussed below), or the drug name octodrine. We then tested the supplements to de- termine what those products actually contained. Of the six products we tested, we indeed found one containing 2-ami- noisoheptane. We also wondered what else could be in the products. Astonishingly, a little more investigative analysis uncovered the presence of two previously unidentif ed 1,3-DMAA analogs: 2-amino-6-methylhep- tane (which is also called octodrine) and 1,4-dimethylamylamine (1,4-DMAA, relat- ed to both DMBA and DMAA). Finally, we also detected the two well-known banned stimulants 1,3-DMAA and 1,3-DMBA. In short, we were surprised to f nd these four dif erent unlawful stimulants—octodrine and 1,4-DMAA, as well as the better-known 1,3-DMAA and 1,3-DMBA—in six pre-workout and weight-loss products that claimed to con- tain either 2-aminoisoheptane or Aconitum kusnezoffii. We found DMBA in one product, DMAA in two other products, and 1,4-DMAA in three products. None of the products' labels disclosed the presence of DMBA, DMAA, or 1,4-DMAA. New research has identifi ed a newly emerging sports-supplement adulterant, 2-aminoisoheptane, reinforcing the need for dietary supplement GMPs, product testing, and independent certifi cation. BY JOHN TRAVIS, SENIOR RESEARCH SCIENTIST, NSF INTERNATIONAL AUTHOR JOHN TRAVIS OF NSF INTERNATIONAL HAS MORE THAN 20 YEARS OF EXPERIENCE ANALYZING DIETARY SUPPLEMENT INGREDIENTS AND ATHLETIC BANNED SUBSTANCES. PHOTO CREDIT: PHOTO FROM NSF INTERNATIONAL SHUTTERSTOCK.COM/ANYAIVANOVA

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