Nutritional Outlook

Nutritional Outlook, December 2016

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research update ■ NUTRITIONAL OUTLOOK 54 deCeMBeR 2016 Lycopene, Lutein May Defend Skin against UV Radiation Grether-Beck S et al., "Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultravio- let radiation: results from a double-blinded, placebo-controlled, cross-over study," Brit- ish Journal of Dermatology. Published online September 23, 2016. New study results shared by carotenoid ingredients supplier Lycored (Be'er Sheva, Israel) suggest that oral supplementation with lutein or a lycopene-rich tomato nutri- ent complex (TNC) may provide skin pro- tection against ultraviolent (UV) radiation at a molecular level. Writing in the British Journal of Dermatol- ogy, researchers report that healthy adult volunteers aged 18–60 who supplemented with TNC or lutein for 12 weeks experienced "complete inhibition" of several genes that can be upregulated by UVA1 and UVA/B- ra- diation, including heme oxygenase-1 (HO-1), intercellular adhesion molecule-1 (ICAM-1), and matrix metalloproteinase-1 (MMP-1). Lycored, which funded the study, hailed the fndings as evidence that its lycopene- rich tomato complex "provides protection against solar radiation–induced health damage." "Tis study suggests that we are slowing down the aging process, because it prevents the damages caused by UV exposure, in- cluding expressions of genes that are bio- markers for skin photo-aging, and oxidative stress on the skin," says Karin Hermoni, PhD, category manager for Lycored, in the study announcement. "On top of that, as part of the photo-aging process we have evidence of the efect of our ingredients on the levels of expression of genes involved in collagen degradation, suggesting a link not only to skin health but also to skin appearance." Te placebo-controlled, double-blind, crossover study included 65 volunteers who were randomized to four treatment groups, with each group consuming either oral TNC or lutein supplements for 12 weeks and a placebo for a separate 12 weeks. Two of the groups started with the active treatment (TNC or lutein) and then switched to the pla- cebo for the second treatment phase, while the other two groups started with placebo and then switched to the active treatment for the second phase. A two-week washout period preceded each treatment phase. Participant skin was irradiated at the be- ginning and end of each treatment phase, with researchers taking biopsies 24 hours after irradiation from each participant's un- treated, irradiated skin. RT-PCR analysis of gene expression performed on the biopsies revealed that both TNC and lutein inhibited gene upregulation that can be induced by UVA1 or UVA/B- radiation, although lutein was found to be signifcantly less efective than TNC at producing these efects in the second treatment phase of the study. B420 Probiotic May Offer Weight-Management Benefts to Overweight Adults Stenman LK et al., "Probiotic with or without fber controls body fat mass, associated with serum zonulin, and obese adults—random- ized controlled trial," EBioMedicine. Published online October 26, 2016. New research results from Finland sug- gest DuPont Nutrition & Health's (Madison, WI) probiotic strain Bifidobacterium anima- lis ssp. Lactis 420 (B420) may reduce body fat mass, waist circumference, and energy intake in overweight adults when taken alone or in combination with a prebiotic. While previ- ous animal studies have found similar efects of B420 consumption, DuPont says this is the frst human study on this strain to ofer such promising weight-management results. Writing in the journal EBioMedicine, researchers report that the double-blind, placebo-controlled study included 225 healthy, overweight or obese (BMI 28.0– 34.9) individuals between the ages of 18 and 65. For six months, participants were randomized to consume one of four treat- ment administrations: 12 g/day of place- bo, 10 10 CFU/day of B420 probiotic, 12 g/ day of prebiotic dietary fber Litesse Ultra polydextrose, or 10 10 CFU/day of B420 pro- biotic plus 12 g/day of the prebiotic fber. Researchers compared baseline measure- ments of body fat mass and energy intake with the same measurements assessed at the end of the administration period. At the end of the study period, both the probiotic and the synbiotic (probiotic plus prebiotic) groups experienced reduced waist circumference and reduced energy intake from baseline, compared to the control group. Te synbiotic group lost an average 1.4 kg in relative body fat mass compared to the placebo group over the course of the study, while a post-hoc factorial analysis re- vealed the group consuming probiotic alone also experienced a signifcant reduction to body fat mass. "Tis clinical trial demonstrates that a probiotic product with or without dietary fber controls body fat mass," researchers concluded. Additionally, in the group consuming both the probiotic and the prebiotic fber, participants experienced improvements in lean body mass, DuPont pointed out. Mean- while, the group that only consumed the prebiotic did not show improvements in the measured outcomes. istoCkphoto.CoM/eXtReMe-photoGRapheR ; istoCkphoto.CoM/shiRhan

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