MDDI_Medical Device & Diagnostic Industry

MDDI, July 2016

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Product Development Insight 16 | JULY 2016 mddionline.com Image courtesy of FROG DESIGN. A New Design for Opioid Overdose Treatment An industrial designer witnessing opioid addiction in his community created a new, improved device designed to deliver treatment in case of an overdose. N ews that Prince's death was a result of opioid overdose has brought more attention to Amer- ica's opioid crisis. If you saw a friend or stranger overdosing on heroin or another opioid, would you know what to do? If you had the treatment for overdose, a medica- tion called naloxone, in hand, would you be able to administer it in time? Jonathan Grossman, an industrial de- signer at Frog Design in San Francisco, was already aware of the opioid addiction crisis and its effects on the community and people he walks by every day in the city. But it wasn't until he watched an online docu- mentary about the opioid epidemic and learned that a naloxone syringe is one of the best weapons against overdose that he re- alized his skills could help improve care for people dependent on opioids. "I'm watching them assemble [the nalox- one syringe] and I'm saying, 'Oh my gosh, this is a terribly designed syringe,'" Gross- man explained. Delivery methods for naloxone include a glass vial and syringe, a nasal atomizer, and an autoinjector. The autoinjector, Evzio, was given priority review and approved by FDA in April 2014. (Evzio was a bronze 2015 Medical Design Excellence Award winner in the drug-delivery devices and combina- tion products category.) At several hundred dollars, Evzio is expensive if purchased by nonprofits, although manufacturer Kaléo does make product donations. A naloxone nasal spray, Narcan, was approved by FDA in November 2015. Narcan was the first FDA-approved nasal spray, though kits that use an atomizer to deliver the injectable version of the drug were already common. These nasal atomizer kits are widely used, but Grossman pointed out that the current design requires nonprofits to assemble the devices, order various quantities of differ- ent components, manage those invento- ries, and ensure each device is put together correctly. Awareness of opioid addiction is increas- ing. In March, the Obama administration announced its plans to battle the opioid crisis, including $11 million in funding to states to buy, distribute, and train people to administer naloxone and other overdose preventive treatments. FDA also recently approved a buprenorphine implant for treatment of opioid dependence. "Opioid abuse and addiction have taken a devastating toll on American families. We must do everything we can to make new, innovative treatment options available that can help patients regain control over their lives," FDA commissioner Robert Califf, MD, said in the FDA release announcing approval of the buprenorphine implant. So while there are overdose prevention options available, there is still plenty of Jonathan Grossman of Frog Design conceptualized a design for a dual-nostril naloxone nasal atomizer, a treatment used in case of opioid overdose. "You'll notice we used heavier plastics and thicker forms that speak to this robust nature so that people won't be worried that it will accidentally administer itself in your bag." Jonathan Grossman, Frog Design

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