MPMN_Medical Product Manufacturing News

Medical Product Manufacturing News, November/December 2015

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Q M E D . C O M / M P M N M E D I C A L P R O D U C T M A N U F A C T U R I N G N E W S N O V E M B E R / D E C E M B E R 2 0 1 5 1 5 3-D Printing at Terminator 2 Levels A company founded by UNC-Chapel Hill professors is touting its new Terminator 2–inspired CLIP technology that promises printing speeds 25 to 100 times faster than the current crop of 3-D printers. Just picture a polymer object literally rising out of a pool of liquid media in minutes rather than the hours it would take for a traditional 3-D printer to lay down material. The UNC-Chapel Hill researchers are now focused on bringing the technology to market through their Redwood City, CA–based startup Carbon3D Inc. As for the technology's Terminator 2 inspiration, the CEO of the company, Joseph M. DeSimone, PhD, explains that he was inspired by the way the next generation T-1000 robot assassin rises out of a puddle of material in that film, as he explained during a TED talk. "We thought, 'Why couldn't a 3-D printer operate in this fashion, where you have an object arise out of a puddle in essentially real time with essentially no waste to make a great object,'" said DeSimone. Enabling Less Painful Dental Anesthesia Injections EG-GILERO (Durham, NC) developed a Local Anesthetic Delivery System for the 10-year-old company Anutra Medical. The system consists of a multi-use dispenser, sterile multi-dose cassette, and a sterile single-use syringe. A vial of lidocaine and a prefilled syringe containing sodium bicarbonate are attached to the cassette and then loaded into the dispenser. The syringe is attached to the valve at the front of the dispenser and dispenses specifically measured buffered lidocaine into the syringe. The syringe allows for aspiration and has integral haptic and audible feedback to aid in anesthetic dispense and delivery to the patient. The onset of buffered lidocaine is up to 90% faster than unbuffered lidocaine, and the injections are less painful. Inherently, buffered lidocaine is unstable over relatively short periods of time, thus the two drugs must be mixed at the point of care. This system allows clinicians to efficiently buffer lidocaine at the patient's side. By using buffered lidocaine, clinicians can perform procedures immediately following administration of anesthetic. This reduces procedure time, improving clinical throughput. Heraeus Medical Components (St. Paul, MN) says its CerMet technology could enable ever tinier implantable medical devices, including biosensors. The reason is that CerMet moves way beyond the older labor-intensive methods of brazing several individual metal pins into an insulating ceramic, according to Heraeus. Instead, a multi-layered printing process creates conductive, even 3-dimensional-shaped, channels into a ceramic matrix. "Our innovation is enabled by a novel biocompatible platinum-based CerMet paste," Heraeus says. "The paste is filled into the cavities of a ceramic sheet using a state-of-the-art printing procedure—even [3-D printing] methods could be applied. After printing, the filled sheets are stacked, laminated, and co-fired to yield a hermetically tight and highly robust compound. Finally, individual parts are singularized and are ready for integration into a housing or a ferrule." Feedthroughs are but one example of how Cermet is a leap forward, according to Heraeus: "Imagine a feedthrough with hundreds of conductive paths in an area as small as your thumbnail. Imagine a three- dimensional feedthrough with bifurcated or angled conductive paths. Imagine a feedthrough as small as the tip of a ballpoint pen." 'Printing' Complex Electronics Encapsulated in Ceramic

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