MPMN_Medical Product Manufacturing News

Medical Product Manufacturing News, September/October 2015

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M E D I C A L P R O D U C T M A N U F A C T U R I N G N E W S Q M E D . C O M / M P M N 2 0 S E P T E M B E R / O C T O B E R 2 0 1 5 Medtronic 5800 External Cardiac Pacemaker (First Produced 1958) Earl Bakken and his brother-in-law Palmer Hermundslie had meanwhile started a business f xing electronic hospital equipment in a Twin Cities garage. Bakken met Lillehei serendipitously at the University of Minnesota Hospital and was tasked with f nding a solution to a pressing problem. Lillehei's infant patients temporarily relied on pacemakers that were plugged into outlets. Every time there was a power outage, they were in danger. It took Bakken four weeks to create the battery-operated external pacemaker, shown here. Some inspiration came from a mention he had read in Popular Science about a transistorized metronome. Bakken's device was used on a patient the f rst day it was delivered to the hospital. Bakken's business, Medtronic, had started on the path to becoming the medical device giant it is today. The company presently rivals Johnson & Johnson as the largest medtech company in the world. REGIONAL FOCUS: MIDWEST Medtech Is Being Honored at the Smithsonian Mayo-Gibbon Heart-lung Machine (Late 1950s) Philadelphia surgeon John Gibbon, MD, is remembered as the inventor of the heart-lung machine. But it was at Mayo Clinic in Rochester, MN, in the late 1950s that John Kirklin, MD, and his co-workers ref ned the machine into what was called the Mayo-Gibbon heart- lung machine—and used it extensively to pioneer open-heart surgery, as recounted in the American Heart Association's Circulation journal. The Mayo-Gibbon device was the most widely used heart-lung machine of the 1950s and early 1960s. Minnesota's "Medical Alley" is one of six locations featured in the new Places of Invention exhibit at the National Museum of American History. DeWall-Lillehei Bubble Oxygenator (1955) Meanwhile, about 80 miles to the north of Rochester in Minneapolis, the University of Minnesota surgery program had become a hotbed or research-based creativity and experimentation under the leadership of Owen Wangensteen, MD, who chaired the program from 1930 to 1967, according to the Smithsonian. One of the most notable pioneers in the program was C. Walton Lillehei, MD, who joined three other surgeons in 1952 to perform the f rst successful, open- heart surgery using hypothermia to slow the heartbeat. The cold temperatures reduced a 5-year-old girl's need for oxygen while the surgeons repaired a hole in her heart. Some children were unable to handle the hyperthermia treatment, so Lillehei experimented with a predecessor to a heart-lung machine called an oxygenator. Eventually, Lillehei and Richard De Wall, a recent University of Minnesota Medical School graduate, developed, tested, and ref ned what the Smithsonian describes as a simple, cheap, eff cient, sterilizable blood oxygenator. H ow did Minnesota become such an important medical device hub in the United States? The history behind that question is part of the new Places of Invention exhibit at the Smithsonian's National Museum of American History in Washington D.C. The exhibit, which opened July 1 and runs until at least 2020, honors the "stories of people who lived, worked, played, collaborated, adapted, took risks, solved problems and sometimes failed— all in the pursuit of something new," according to the Smithsonian. The six places highlighted in the exhibition include Silicon Valley (personal computing); Hollywood (Technicolor); the Bronx (hip-hop); Hartford, CT (precision manufacturing); Fort Collins, CO (clean energy innovation); and last but surely not least—Minnesota's "Medical Alley" and its cardiac innovation. Here are some of the innovative medical devices highlighted in the exhibit.

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