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Pharmaceutical & Medical Packaging News, May/June 2015

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37 May/June 2015 Pharmaceutical & Medical Packaging News • PharmaPaCk North ameriCa 2015 Ron Linssen, Ecobliss managing director, in an email to PMP News. "It is truly the first child-resistant carton that can run on a regular cartoning machine, like Roma- co, at the same speed as normal cartons." With Locked4Kids, you can pack as many blister strips with medicine as required, Linssen added. "The packaging is low cost as compared with other child- resistant solutions." Since launching the product in Octo- ber 2014 in Paris and a month later in Chicago, the concept has been accepted by many pharmaceutical companies, and "quite a number of different products have already been sampled," Linssen said. The carton won the Dutch packaging award, the Zilveren Noot 2014, as well as an award at CPhI for "best innovation in packaging." The idea for Locked4Kids began a few years ago when the decision was made to start development of what Lins- sen calls the "world's first child-resistant carton." At Ecobliss, parent company of Locked4Kids, Linssen said they are always looking for ways to improve exist- ing packaging and packaging processes. "It is fascinating and very difcult to find balance between what young children should not be able to open, while keeping easy access for seniors," he said. The packaging concept was developed by Ecobliss for a broad array of pharma- ceutical, chemical, and toxic products in solid, powder, or liquid form, and the cooperation with Romaco began to take form at Interpack 2014 in Dusseldorf, Germany. Linssen said they have pro- duced carton samples in many diferent sizes, ranging from boxes with a width of 50 to 85 millimeters and length of 120 to 200 millimeters. Locked4Kids packaging has been designed to include blister strips with medicine. Once assembled, Linssen notes, all parts of the packaging stay connected, even after the packaging is opened. Other products can be packed into a Locked4Kids carton. It contains special blister trays with small hooks on the long sides. The hooks are placed diagonally from each other so that the tray is locked securely when it is pushed right in. In order to remove the tray, both hooks have to be released simultaneously by pressing firmly and evenly on the box at the marked points with the thumb and forefinger, in an intention to be easy for adults but impossible for children Also, both sides of the box are coated in tear- resistant laminate to prevent children from ripping it apart. The Romaco Promatic P91S inter- mittent-motion cartoner packages the Locked4Kids blister trays in laminated carton boxes, outputting 80 packs a min- ute. The asymmetrical hooks attached to the trays required careful feeding, and due to its unusual geometry, the trays require additional stabilization while they are being positioned in the carton boxes. Once the packs are produced, the lam- inated carton boxes are removed and opened using Romaco's positive carton opening system. In the United States, Ecobliss has licensed North Carolina-based Atlantic Packaging. "Locked4Kids has been devel- oped to meet the highest rating set by the U.S. Consumer Product Safety Commission [F=1]. Besides Atlan- tic we are in contact with a number of pharmaceutical US-based compa- nies that want to get a license for the production of Locked4Kids," he says. Nemera's Novelia eyedropper Drug-delivery manufacturer Nemera (formerly Rexam Healthcare) anticipates its preservative-free multidose eyedrop- per Novelia to have an impact at Phar- mapack North America Booth #4007 after gaining traction in Europe and Latin America since its debut. Novelia is touted as the only preservative-free multi- dose system on the U.S. market. Novelia is the key patient-oriented innovation for Nemera, following the sale of Rexam Healthcare in 2014 and the renaming of the devices business unit. Novelia has been promoted for several years on the market since 2012, accord- ing to Fanny Sellier, global category manager for Nemera's ophthalmic prod- ucts. Developments have been made to the product since then. Sellier tells PMP News there is already a U.S. company commercializing Nov- elia but cannot yet reveal the name. In Europe, Novelia has been branded on products for Hyprosan, Clinitas Soothe, and Xiloial Zero, to name a few. The device is being commercialized in many over-the-counter brands worldwide as well, Sellier added, and as a packaging of drug product in six European countries. To avoid bacterial contamination, Sellier said preservatives are required and contained in about two-thirds of mul- tidose eyedroppers in the ophthalmic packaging market. Nemera credits Novelia's patented PureFlow technology, used for both air filtration and flow control, to dispense one drop at a time. The soft bottles come in five size ranges from 5 milliliters (stan- dard) up through 20 milliliters. "Basically Novelia is a self-preserved system," Sellier said. "Novelia functions with a non-return valve that avoids any potential contaminated liquid to come back into the bottle, and [it has] a pat- ented venting system that allows air com- pensation and blocks bacteria. The fact The Locked4Kids special blister package.

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