IVDT_In Vitro Diagnostics Technology

IVD Technology, Fall 2013

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POINT-OF-CARE DIAGNOSTICS Surface Acoustic Waves Advance POC Diagnostics A smartphone-based biosensor technology allows infectious-disease testing to be performed in minutes. BY DALE ATHEY I nfectious diseases afict millions of people every year. Tese hard-hitting viruses can rapidly sweep through populations and, in some cases, whole continents in a matter of weeks. Identifying and treating these diseases has considerable cost implications for health protection services, and places a further strain on already overburdened healthcare systems, delaying treatment and endangering human lives. Speed is of the essence for the successful treatment of many infectious diseases. Antiviral drugs are at their most efective within the frst three days of onset of symptoms, so the value to medical staf of having access to easy-to-use, quick and reliable ways to test patients, whether they are in a local clinic or a remote village hundreds of miles from the nearest healthcare facility, cannot be overstated. As a result, there is a strong international trend to move the testing and monitoring of infectious diseases outside the confnes of specialist hospitals by using point-of-care (POC) diagnostics. A new generation of advanced POC testing and detection technologies leverage biosensors and smartphones and have the potential to transform the way fu and other infectious diseases are diagnosed. Advanced POC diagnostics combines specialist biosensor materials and electronics in a handheld device for the accurate detection of illnesses from patient supplied samples. One example is a mobile phone–enabled biosensor from medical device and diagnostic specialist OJ-Bio, a joint venture between UK-based biotechnology company Orla Protein Technologies Ltd. and the Japan Radio Co. (JRC). In this collaboration, Orla provides the specialist biosensor materials that are combined with JRC's advanced electronics capability to create a specialist biochip technology platform. Shear horizontal surface acoustic wave (SAW) chips are coated with protein-based capture reagents to create a device that gives highly specifc responses when coming into contact with samples containing markers of the disease concerned. Te reaction that takes place is turned into an electronic signal, which can be captured by a small reader that receives and transmits data in real time. SAW chips have been commercially available for more than 40 years; they are widely used in the telecommunications industry and base stations where they act as band-pass flters. Te combination of novel antibodies, nanoparticles and multiplexing methods enables SAW technology to be used efectively with biological samples for the frst time. Te resulting devices already can detect antigens in samples from serum, urine, or saliva. Te chips are designed and manufactured to operate in liquids with high sensitivity and to perform as an immunoassay device that detects mass and viscosity changes caused by binding of the target analyte to the surface of the SAW sensor device. Te chips are fabricated using a delay line on quartz substrates that 20 IVD TEC HNOL O G Y | FA L L 2013 magenta cyan yellow black ES320493_IV1309_020.pgs 09.19.2013 01:50 UBM

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