Nutritional Outlook

Nutritional Outlook, September 2013

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Cognitive Health creased following the oral administration of grape seed extract. Similar studies on other favonoids—including epigallocatechin gallate (EGCG) from green tea, favanones from citrus and tomatoes, favonols from Ginkgo biloba, and anthocyanins from berries—show that these compounds also penetrate brain tissue (Free Radical Biology & Medicine, 2012). In addition to crossing the blood-brain barrier, studies indicate that favonoids actually accumulate in areas of the brain that are critical for neural functioning and memory, and areas that play a role in pathological processes associated with dementia and other diseases. Tis is a critical aspect of their ability to confer biological efects. As an example, Cristina Andrés-Lacueva and colleagues from the University of Barcelona and the USDA Human Nutrition Research Center on Aging at Tufts University found that the administration of blueberries to rats led to detection of anthocyanins in the cerebellum, cortex, hippocampus, and striatum of the brain (Nutritional Neuroscience, 2005). Mechanisms for Brain Support In the context of Alzheimer's disease, Robert Williams from the University of Bath, and Jeremy Spencer from the University of Reading in the United Kingdom, authored a review summarizing the potential therapeutic utility of favonoids for cognitive function and dementia (Free Radical Biology & Medicine, 2012). While conventional wisdom regarding the biological activity of favonoids centers on their direct antioxidant potential, the authors proposed that antioxidant activity is not the primary mechanism of favonoid benefts to the central nervous system; Solutions for Healthy Aging. Zinc. Magnesium. Selenium. These minerals contribute to brain and nervous system health and psychological functions. But the human body needs proper absorption of these vital nutrients to gain their benefits. We have the solution. Our premium chelated mineral formulations are designed for bio-availability, stability, solubility, and compressibility for manufacturers in the nutritional supplement, sports nutrition, and functional food segments. With Kelatron and AMT Labs as your partners, you can provide your customers solutions for healthy aging through the power of mineral chelates. Ask us about our K-Pure and ChelaMax range of premium chelated minerals. An Innophos Company An Innophos Company 36 magenta cyan yellow black Kelatron 800.201.6896 | www.kelatron.com AMT Labs www.amtlabs.net Antioxidant activity may not be the primary mechanism of favonoid benefts to the central nervous system. rather, the potential of favonoids to beneft neurological health is likely related to three distinct and broad areas: (1) their ability to interact with intracellular signaling pathways in brain cells; (2) their infuence on the peripheral and cerebral vascular system (enhancing blood and nutrient circulation); and (3) their potential to reduce neuron damage that results from toxic compounds and infammatory processes. Brain-Cell Signaling Research on the interactions between favonoids and brain cells reveals that native favonoids and their intestinal metabolic byproducts actively bind to neurons. Several favonoid binding sites have been discovered on brain cells, while a specifc binding SEPTEMBER 2013 ■ NUTRITIONAL OUTLOOK ES315725_NO1309_036.pgs 09.04.2013 04:16 UBM

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